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    Akt activation is governed by a dual regulatory mechanism in which it is first recruited to the cellular plasma membrane by PIP3 through a direct interaction with the PH domain of Akt
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    Akt signaling refers to a cellular signaling pathway involving the Akt protein, a serine threonine kinase that, when activated, influences various biological processes such as cell survival, growth, and metabolism, particularly in cancer cells
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    Thus, the systematic versus cell-autonomous deletion of Akt isoforms could result in distinct impacts on cancer phenotypes In this review, we summarized the recent provocative findings on Akt regulations and their roles in signaling and cancer control as well as therapeutical implications





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