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  • Rechallenge therapy versus tyrosine kinase inhibitor (TKI . . .
    Abstract Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine tipiracil (TAS-102), but these drugs have limited clinical efficacy This study aims to evaluate the efficacy and survival outcomes of tyrosine kinase inhibitor (TKI) versus chemotherapy rechallenge in third-line treatment for
  • High-dose short-term osimertinib treatment is effective in . . .
    Most tyrosine kinase inhibitors (TKIs) have failed in clinical trials for metastatic colorectal cancer (mCRC) To leverage the additional lower-affinity targets that most TKIs have, high-dose
  • Zanzalintinib Atezolizumab Improves CRC Survival, Expands TKI . . .
    New trial results reveal zanzalintinib and atezolizumab significantly enhance survival in metastatic colorectal cancer, marking a breakthrough in treatment options
  • Lost in translation: Revisiting the use of tyrosine kinase . . .
    Patients with advanced or metastatic colorectal cancer ( (m)CRC) have limited effective treatment options resulting in high mortality rates A better understanding of the molecular basis of this disease has led to growing interest in small molecule tyrosine kinase inhibitors (TKIs) for its treatment
  • Exploring research frontiers and emerging trends of tyrosine . . .
    Background Tyrosine kinase inhibitors (TKIs) are a class of molecular targeted drugs designed to selectively inhibit tyrosine kinase activity associated with oncogenic signaling pathways and drivers, and have emerged as key therapeutic agents for colorectal cancer (CRC) The purpose of this study is to explore the research status and development trend of TKIs in CRC treatment Methods The Web
  • Multi-omics characterization of response to tyrosine kinase . . .
    Multi-omics characterization of response to tyrosine kinase inhibitor plus immunotherapy in MSS pMMR metastatic colorectal cancer: A multicenter biomarker study If you have the appropriate software installed, you can download article citation data to the citation manager of your choice
  • Abstract 5768: Repurposing veratridine, a previously used . . .
    Abstract Despite significant advances in improving colorectal cancer (CRC) survival over the past decade, therapeutic challenges persist due to the rapid spread of primary tumors The rising incidence of early-onset colorectal cancer (patients under age 50) across all ethnicities has created another major health concern, as these patients are often diagnosed with advanced, metastatic disease
  • Fruquintinib as new treatment option in metastatic colorectal . . .
    Introduction Available treatments for colorectal cancer are limited However, in the last few years several advances and new treatment options became available and expanded the continuum of care in metastatic colorectal cancer (mCRC)
  • Combination IO TKI Strategies in Metastatic Colorectal Cancer
    A comprehensive review on combination strategies with immune checkpoint and tyrosine kinase inhibitors in patients with metastatic colorectal cancer
  • Immune checkpoint inhibitor in third-line treatment of . . .
    I is a beneficial addition to third-line treatment for some MSS mCRC patients, providing improved survival benefit and controllable safety, and a directional OS improvement Background The third-line treatment options recommended by guidelines for metastatic colorectal cancer (mCRC) are limited with unsatisfactory efficacy Immune checkpoint inhibitor (ICI)-based strategies have been





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