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  • Variant of Uncertain Significance (VUS)
    When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
  • What to do if your genetic test finds a variant of uncertain . . .
    But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
  • Assessing a Variant of Uncertain Significance (VUS)
    Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
  • What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . .
    What to do if your genetic test results include a VUS If you have one or more VUSs in your genetic test results, the most important next step is to talk with a neuromuscular specialist or genetic counselor They can look at the whole picture and decide what, if anything, to do next
  • Understanding genetic variants of uncertain significance - PMC
    If a VUS is found to be inherited from an unaffected parent, the variant is less likely to be pathogenic If a child has two VUSs in a gene that typically cause disease in an autosomal recessive manner, testing parents will clarify if the VUSs are in the same or different copies of the gene
  • Genetic Test Result: VUS - Variant of Uncertain Significance
    A VUS result could get changed to either benign or pathogenic with new information For some variants, a different test can measure if the gene is working or not
  • VUS Variant of Uncertain Significance for cancer patients - MC1185-82
    Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
  • GENERAL GUIDELINES VUS RESULTS GUIDE - Labcorp
    ed to test family members for a VUS In some cases, the genetic testing report will indicate that testing family mem tives have their own genetic makeup Although these results did not find a significant genetic change, family members can discuss their own potential health and or reproductive risks and the option of genetic testing
  • Prioritizing potentially cancer-causing mutations in real-world cancer . . .
    Overview of a framework for prioritizing variants of uncertain significance (VUS) identified by comprehensive genomic profiling (CGP), based on real-world data from 2,172 tests showing a higher





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